Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell and is essential for hundreds of metabolic processes. Its critical role in energy metabolism, DNA repair, and cellular signaling has made it a focal point of longevity research.
Why NAD+ Declines With Age
NAD+ levels decline by approximately 50% between the ages of 40 and 60 in most tissues. This decline is associated with mitochondrial dysfunction, increased inflammation, decreased cellular resilience, and the hallmarks of metabolic aging.
IV Administration vs. Oral Supplementation
While oral NAD+ precursors (NMN, NR) have demonstrated efficacy in increasing cellular NAD+ levels, intravenous administration provides a more rapid and predictable increase in plasma NAD+ concentration. Clinical observations consistently report improvements in energy, cognitive clarity, and mood within hours of IV administration.